Metagenomics

Besides the infectious agents themselves, the interaction with the host microbiota has also an important influence on the course and outcome of the infection. Hence, the aim of the research clusters is to catalogue all microorganisms present in a given ecological niche and to determine the species composition and the dynamics of microbial communities of healthy and diseased individuals. This knowledge will contribute to the development of novel preventative and therapeutic methods.

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Genome Variability

The research focus of this cluster is the analysis of the genomic variability within a pathogenic species and its adaptation to the host organism during the infectious process. The improved understanding of the evolution and spread of infectious agents will contribute to the development of novel approaches in the monitoring and prevention of future epidemics.

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Functional Quantitative Genomics

Both research clusters address the quantitative analysis and profiling of infectious processes. They aim at unravelling the molecular as well as cellular basis of infections and the identification of factors which contribute to the development and outcome of infectious disease. This knowledge will ultimately serve as a basis for improved methods for the diagnosis and therapy of infectious diseases.

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Protein Profiling

The research clusters investigate the complex interplay between infectious agents and the human host by analysing all proteins involved in the infection process. This will lead to the identification of novel virulence factors and target structures, and will build the basis for the development of new strategies for the prevention and treatment of infectious diseases.

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